DIFFERENTIAL SENSITIVITY OF MOUSE SPERMATOGENESIS TO ALKYLATING AGENTS
نویسندگان
چکیده
منابع مشابه
Differential sensitivity of mouse spermatogenesis to alkylating agents.
ARIOUS alkylating agents have long been used for inducing mutations and Vchromosome breaks in some plants and animals. Effects on Drosophila spermatogenesis have been investigated by AUERBACH (1940, 1949, 1958), especially with mustard gas, and FAHMY and FAHMY (1953, 1956) used various compounds. All types of mutations have so far been obtained-dominant lethals and semilethals, recessive lethal...
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The long-patch mismatch repair pathway contributes to the cytotoxic effect of methylating agents and loss of this pathway confers tolerance to DNA methylation damage. Two methylation-tolerant mouse cell lines were identified and were shown to be defective in the MSH2 protein by in vitro mismatch repair assay. A normal copy of the human MSH2 gene, introduced by transfer of human chromosome 2, re...
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Only some imprinting control regions (ICRs) acquire their DNA methylation in the male germ line. These imprints are protected against the global demethylation of the sperm genome following fertilisation, and are maintained throughout development. We find that in somatic cells and tissues, DNA methylation at these ICRs is associated with histone H4-lysine-20 and H3-lysine-9 trimethylation. The u...
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Several possible mechanisms of resistance to alkylating agents have been posed and discussed on the basis of presently available experimental data. The two mechanisms that appear to be most plausible are altered cell permeability toward the agents and deactivation of the agents by combination with nonprotein sulfhydnyl groups. These two mechanisms might function simultaneously and might contrib...
متن کاملThe Mechanism of Action of Alkylating Agents.
The term “alkylating agent― has been defined and a detailed discussion made of the mechanisms (Sni and Sn@) by which they interact with nucleophilic centers. The various nucleophiles likely to be encountered in vivo are discussed in terms of their relative reactivities toward alkylating agents. With regard to Sn@ reactors it was possible to group them into four sections on the basis of thei...
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ژورنال
عنوان ژورنال: Genetics
سال: 1961
ISSN: 1943-2631
DOI: 10.1093/genetics/46.3.291